Klonopin (Clonazepam)
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Description of the drug Klonopin
Klonopin (Clonazepam) is a benzodiazepine derivative that has an anticonvulsant, anxiolytic, muscular-relaxing, amnestic, sedative, and hypnotic effect. It reduces the excitability of the subcortical areas of the brain (limbic system, thalamus, and hypothalamus) and disturbs their interaction with the cortex. It oppresses polysynaptic spinal reflexes. It is quickly and completely absorbed in the digestive tract. After taken orally, Cmax is achieved in 1-2 hours. It is excreted mainly in urine. 1 tablet contains 0.5 or 2 mg of Clonazepam; one blister contains 30 pcs, one pack contains 1 blister.
Indications for use
Syndromes of paroxysmal fear, phobias (in patients older than 18 years);
Epilepsy in children and adults (myoclonic and akinetic epilepsy, generalized submaximal, temporal, and focal seizures);
Manic phase of cyclothymia, psychomotor agitation in reactive psychoses.
Contraindications for use
Hypersensitivity, impairment of consciousness, central respiration disturbance, respiratory failure, glaucoma, myasthenia gravis, severe liver function disorders. It is contraindicated for people under 18 years of age (in the case of paroxysmal fear).
Side effects
Ataxia, discoordination, fatigue, drowsiness, weakness, dizziness, impaired memory and speech, visual disturbances, nervousness, weakening of the ability to learn, emotional lability, decreased libido, confusion, depression, symptoms of catarrhal inflammation of the upper respiratory tract, hypersalivation, constipation, abdominal pain, loss of appetite, muscle pain, menstrual disorders, urinary frequency, erythromycin, leukopenia and thrombocytopenia, increased blood concentrations of transaminases and alkaline phosphatase, paradoxical reactions – excitement, cutaneous allergic manifestations, insomnia (it requires drug withdrawal).
Dosing and Administration
Klonopin (Clonazepam) is taken orally. Epilepsy: for adults – the initial dose is 1.5 mg/day in 3 divided intakes, followed by an increase by 0.5-1 mg every 3 days, the maintaining dose is 4-8 mg/day in 3-4 intakes; the maximum dose is 20 mg/day; for children – the initial dose – 1 mg/day in 2 divided intakes, then followed by an increase by 0.5 mg every 3 days, the maintaining dose in children under 5 years is 1-3 mg, the maintaining dose in children under 5 to 12 years is 3-6 mg/day, the maximum dose is 0.2 mg/kg/day. Syndrome of paroxysmal fear in adults: 1 mg/day (maximum 4 mg/day).
Precautions
It should be taken with caution in the case of the kidney and liver dysfunction, chronic diseases of the respiratory system, elderly age (over 65 years). Long-term use leads to a weakened effect. Do not drink alcohol during treatment. In the case of the cancellation of therapy, the dose is reduced gradually, since a one-stage discontinuation of the drug (especially after a long course) can lead to the development of psychophysical dependence and the emergence of an abstinence syndrome. You cannot drive vehicles and service moving mechanical devices during the treatment period.